Senescent Cells & Senolytics

Senescent cells are "zombie cells" — they stop dividing but refuse to die. Instead, they secrete a toxic cocktail called the senescence-associated secretory phenotype (SASP): inflammatory cytokines, matrix metalloproteinases, and growth factors that damage surrounding healthy tissue and accelerate aging in neighboring cells.

How FOXO4-DRI Works

FOXO4-DRI is a D-retro-inverso peptide that specifically disrupts the FOXO4-p53 interaction that keeps senescent cells alive. By blocking this survival mechanism, FOXO4-DRI triggers p53-mediated apoptosis exclusively in senescent cells while leaving healthy cells unaffected. This is the most targeted senolytic approach available.